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Diablo 4 Immune Status Ailment Explained

Hey there, fellow gamers! Brace yourselves for an exciting and informative guide all about the Immune status effect in Diablo 4. Immune is a powerful state that can drastically impact both player characters and formidable NPCs, especially those daunting high-level bosses. In this article, we will delve deep into the world of Immune, revealing how to recognize this status ailment on your Health Globe, the skills that create or modify Immune, and the various Gems, Item Affixes, and Legendary Aspects that can enhance and strengthen Immune. Don’t miss out on this opportunity to gain a competitive edge and conquer the Immune status effect!

Note: The information provided is based on available details during the Diablo 4 Beta Weekends and is subject to change in the final release. Stay tuned for updates as the game progresses. Now, let’s dive into the captivating world of Immune in Diablo 4!

What Is Immune in Diablo 4?

In Diablo 4, Immune is a formidable status ailment that renders a character or NPC invulnerable to damage and negates all adverse effects. When a character or NPC becomes Immune, they are impervious to harm, making it impossible to inflict damage upon them or apply any adverse effects.

While there are a few class skills that can provide Immunity, it’s worth noting that neither the Barbarian nor the Rogue classes have access to such skills. However, there are certain Legendary items that grant Immunity, and you can acquire one of them as a reward upon completing the Act I Campaign.

When facing an Immune NPC, you’ll find that crowd control effects, such as building Stagger, won’t work against them until their Immunity is broken. To overcome this challenge, you may need to defeat mobs or destroy objects protecting the boss and causing their Immunity. Alternatively, you can adopt a defensive strategy and wait for the Immunity phase to pass.

It’s important to remember that attacking an Immune NPC with resource builders will be futile, as it won’t generate any resources for you. Instead, focus your efforts on eliminating non-immune mobs, disrupting the elements that grant Immunity to the boss, or adopting defensive tactics to endure the encounter.

Mastering the mechanics of Immune in Diablo 4 is crucial for overcoming powerful adversaries and progressing in your adventures. Stay vigilant, adapt your strategies, and unleash your might when the time is right!

Diablo 4 Immune System and Basic Rules

Let’s dive into the basic rules of the Immune system in Diablo 4. When a character becomes Immune, they become invincible, making them impervious to damage and immune to all negative effects. It’s a powerful state that grants them temporary invulnerability.

In addition to Immunity, there are several status effects in the game that can affect enemies. Here are some of them and how they interact with Immune characters:

  • Knockdown: This status effect temporarily prevents enemies from moving or taking action. However, it can be removed through Unstoppable or Immune effects.
  • Dazed: When an enemy is Dazed, they are unable to attack or use skills for a short duration. Although they can still move, they are unable to perform offensive actions. Dazed can also be removed through Unstoppable or Immune effects.
  • Tether: Tether is a status effect that restricts enemies from moving beyond a certain radius. It can be removed by either applying Unstoppable or Immune effects or by destroying the target that the enemy is tethered to.
  • Fear: Fear causes the affected target to run away for a short duration, preventing them from moving or taking action. Like the other status effects, Fear can be removed through Unstoppable or Immune effects.

Understanding these basic rules of the Immune system and its interaction with other status effects is essential for devising effective strategies in combat. Utilize your skills wisely, seek opportunities to remove or bypass Immunity, and exploit the vulnerabilities of your enemies to emerge victorious.

How Does Immune Look Like?

When an NPC, especially a boss, is Immune in Diablo 4, their status bar turns gray. It indicates their state of invulnerability. You’ll notice that until their status bar turns red, they are still Immune. For example, in the Vhenard fight during the Fractured Peaks Act 1 campaign, you must defeat the Hell Spawns she summons to remove her Immunity. These Immune-granting adds are often connected to the boss by a visible spell or tether.

Another example is the Knight Penitent in the final fight of the Act 1 campaign, who casts an Immune bubble at phase changes. The Immune bubble appears as a large protective bubble around the character or boss. Players can utilize these Immune bubbles to escape damage or remain invulnerable during certain encounters, making them highly valuable in World Boss fights.

What Classes Have Immune Skills?

In Diablo 4, the Immune status ailment is the rarest skill available among the status buffs. Among the classes, the Druid possesses the skill called Lacerate, which grants them the ability to become immune to damage and negative effects. The Necromancer has the Blood Mist skill, which provides immunity to damage and negative effects as well. Lastly, the Sorcerer has two skills that grant immunity: Flame Shield, which protects against damage, and Deep Freeze, which freezes enemies and renders them unable to move or attack. These skills offer powerful defensive capabilities, allowing players to strategically navigate battles and overcome challenging encounters.

Immune Legendary Aspects

There is a powerful Legendary Aspect called “Protecting Aspect that can grant the Immune status ailment. This Aspect is unique in that it can be used by any class, allowing players to enjoy the benefits of Immunity regardless of their chosen playstyle. The Protecting Aspect provides a strong defensive boost, creating a protective bubble around the player character that renders them immune to damage while inside. This makes the Protecting Aspect highly sought after among adventurers, offering a valuable layer of defense during intense battles and challenging encounters. So keep an eye out for this Legendary Aspect and harness the power of Immunity to overcome even the toughest foes in Sanctuary.

In Conclusion


The Immune Status Ailment plays a significant role in gameplay, both for player characters and NPCs. Being Immune means that a character or enemy cannot be damaged, and all negative effects are removed or prevented. While Immunity is rare and usually associated with high-level bosses, there are ways to break through Immunity, such as defeating protecting mobs or destroying objects. Players need to be strategic and patient during the Immune phases, focusing on other non-immune targets or adopting defensive tactics. Understanding the Immune system is crucial for success in challenging encounters and boss fights. Additionally, certain classes and legendary aspects offer skills and abilities that can grant Immunity, providing players with an advantage in combat. So, master the Immune system, harness its power, and conquer the dark forces that await in the world of Diablo 4!

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